What do aryl hydrocarbon receptors do?
Sarah Marsh What do aryl hydrocarbon receptors do?
The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor that integrates environmental, dietary, microbial and metabolic cues to control complex transcriptional programmes in a ligand-specific, cell-type-specific and context-specific manner.
Where is the aryl hydrocarbon receptor AHR located within the cell?
cytoplasm
In the absence of bound agonist, the AHR is most commonly found in the cytoplasm in a complex with its chaperones heat shock protein 90 (Hsp90), P23 and aryl hydrocarbon receptor associated 9 (ARA9; aka AIP, XAP2).
What is an AHR ligand?
The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor that is best known for mediating the toxicity and tumour-promoting properties of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD; commonly referred to as ‘dioxin’).
What is AHR pathway?
The AhR genomic pathway. When a ligand crosses the plasma membrane (passive diffusion), it binds to the AhR (the PAS B domain). This allows the translocation of the ligand-receptor complex into the nucleus and the dissociation of the receptor complex.
What is aryl hydrocarbon hydroxylase?
Aryl hydrocarbon hydroxylase (AHH) is a multicomponent, microsomal-bound enzyme system which converts a variety of lipid-soluble compounds to water-soluble forms for subsequent elimination from the body.
What is AHR antagonist?
AHR (Aryl-hydrocarbon receptor; also bHLHE76) is a 110 kDa member of the bHLH/PAS transcription factor family. It is widely expressed (breast, lung, liver), and serves many functions. First, it binds multiple xenobiotic chemicals in the cytoplasm.
How does aryl hydrocarbon receptor signaling contribute to obesity related cancers?
Studies have shown that the toxicant-activated aryl hydrocarbon receptor (AHR) may disrupt fat metabolism and contribute to obesity. The AHR is a nuclear receptor/transcription factor that is best known for responding to environmental toxicant exposures to induce a battery of xenobiotic-metabolizing genes.
What is an AHR agonist?
The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor with important functions in the immune response and cancer. AHR agonists are provided by the environment, the commensal flora and the metabolism. These observations suggest that cell-specific factors influence AHR activation and signaling.
What is the meaning of AHR?
Acronym. Definition. AHR. American Historical Review (Journal of the American History Association) AHR.
Where is AHR expressed?
In adult humans, AhR mRNA is highly expressed in lung, pancreas, liver, and heart, with lower levels of expression in brain and kidney (Dolwick et al. 1993b).
