Does dofetilide cause kidney problems?

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of dofetilide in the elderly. However, elderly patients are more likely to have kidney problems, which may require caution and an adjustment in the dose for patients receiving dofetilide.

What are some considerations when administering TIKOSYN?

TIKOSYN Treatment Guidelines TIKOSYN must be initiated in a setting that provides continuous electrocardiographic (ECG) monitoring and in the presence of personnel trained in the management of serious ventricular arrhythmias. Patients should continue to be monitored in this way for a minimum of 3 days.

Which creatinine clearance value is contraindicated for administration of dofetilide?

Dofetilide is contraindicated in patients with a creatinine clearance of < 20 ml/min.

What should I monitor with dofetilide?

Monitor for ECG changes if therapy is initiated in patients with drugs known to prolong QT interval. dofetilide and panobinostat both increase QTc interval. Avoid or Use Alternate Drug. Panobinostat is known to significantly prolong QT interval.

Does Tikosyn affect kidney?

You should not take Tikosyn if you have severe kidney disease or a history of Long QT syndrome. Serious drug interactions can occur when certain medicines are used together with Tikosyn.

What is the success rate of Tikosyn?

In total, 148 patients treated with TIKOSYN (59%) and 86 patients treated with placebo (34%) were restored successfully to NSR (either pharmacologically or by direct current cardioversion).

How long should a patient be off amiodarone prior to starting TIKOSYN?

Drug guidelines mandate a 3-month waiting period before initiating dofetilide after amiodarone use.

What medications are contraindicated with TIKOSYN?

The concomitant use of verapamil or the cation transport system inhibitors cimetidine, trimethoprim (alone or in combination with sulfamethoxazole), or ketoconazole with TIKOSYN is contraindicated (see WARNINGS and PRECAUTIONS, Drug-Drug Interactions), as each of these drugs cause a substantial increase in dofetilide …

Is there a black box warning for dofetilide?

Dofetilide has a Black Box Warning and may be subject to Risk Evaluation and Mitigation Strategy (REMS) under FDA safety regulations. Please refer to individual prescribing information for details. The recipient has a diagnosis of ONE of the following: Atrial fibrillation; OR.

What medications are contraindicated with Tikosyn?

Does TIKOSYN affect potassium?

Potassium levels should be within the normal range prior to administration of TIKOSYN and maintained in the normal range during administration of TIKOSYN (see DOSAGE AND ADMINISTRATION).

Can you take furosemide with dofetilide?

Using dofetilide together with furosemide can increase the risk of an irregular heart rhythm that may be serious. If your doctor prescribes these medications together, you may need regular monitoring of your electrolyte (magnesium, potassium) levels as well as other tests to safely use both medications.